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silybum marianum monograph

Silymarin counteracts the toxic effects of a wide variety of liver poisons, including alcohol, carbon tetrachloride (used widely in the dry-cleaning industry) acetaminophen and the death cap mushroom, which can cause death within a day. Saller R, Brignoli R, Melzer J, Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Preliminary evidence suggests milk thistle may reduce side effects such as hepatotoxicity, nephrotoxicity, radiation-induced mucositis and dermatitis, … Milk Thistle Monograph: (Silybum marianum) Alternative Medicine Review 1999 (Aug); 4 ( 4): 272–274 ~ FULL TEXT Silybum marianum (milk thistle) has been used for centuries as an herbal medicine for the treatment of liver disease. See certificate for values and more details Phytochemicals: Silybin A+B (quantitative); Silicristin, Silidianin, Isosilibinin A, Isosilibinin B (qualitative) European Union herbal monograph on Silybum marianum (L.) Gaertn., fructus 1. 2. DIDB drug monograph DDI summaries are composed when the drugs are first approved by the FDA and are based on data curated mainly from NDA reviews and drug labels. 1.2.1 Utilization Powdered milk thistle extract United States Pharmacopeia (USP) Reference Standard; CAS Number: 84604-20-6; Synonym: Silybum marianum extract, Milk thistle extract; find USP-1443850 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Family: Asteraceae Part used: Fruit/Seed Constituents: Flavolignans (silymarin complex), flavonoids, volatile oil, bitter principle, mucilage Actions: Cholagogue, hepatic, hepatoprotective & hepatorestorative, galactagogue, demulcent Medical uses: Research has shown that it promotes the regeneration of diseased liver cells and protects them … World Health Organization. It has been naturalized in South America, North America, and Southern Australia and requires warm, dry soil to grow (1). Ingredient Type:Botanical, Extract Also Known As: Silybum marianum extract, Silymarin, Mary thistle extract, Holy thistle extract Silybum marianum or milk thistle is a plant from the Asteraceae family, native to Southern Europe, parts of the Middle East, and Northern Africa. It has been studied for use in allergic rhinitis, asthma, cancer treatment–related adverse effects, rheumatoid arthritis, type 2 diabetes, drug-induced hepatotoxicity, drug-induced nephrotoxicity, dyslipidemia, and thalassemia; however clinical trials supporting these uses are limited. ♦ provide a model monograph as a basis for countries and researchers to develop further monographs on good agricultural and collection practices (GACP) for other medicinal plants; ♦ protect the wild resources of medicinal plants, in particular Artemisia annua L., to ensure their sustainable use. Milk thistle herbal preparations are produced from the seeds of Silybum marianum (L.) Gaertn. Beauty & Radiance Support, Digestive Support, Liver & Cleanse Support. In a study investigating the effects of this formula, by looking closer at the impact of the single extracts included, found that C. scolymus was able to … To be specified for the individual finished product. 2: Fructus Silybi Mariae. Generic Name: strychnos nux-vomica seed, silybum marianum seed, silicon dioxide, potassium phosphate, dibasic and sodium sulfate Dosage Form: tablet Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. Silybum marianum . variegated thistle. Herbal monograph for Milk thistle includes parts used, how to use as an herbal medicine, dosage and contraindications. Intensive research in the hepatoprotectant (liver protecting) effects of milk thistle began about 40 years ago. Qualitative and quantitative composition 1, 2 ... Much of the modern day research has been conducted in Germany where it is an approved herb in The German Commission E Monographs. Silybin predominates, followed by silydianin and silychristin. Name of the medicinal product. In the U.S. in 2000, milk thistle ranked 11th in sales of all herbal products sold in food, drug, and mass market outlets, reaching about $9 million in retail sales. To retrieve all information on milk thistle (Silybum marianum), including data published post-approval, use the all studies query. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. It is in leaf all year, in flower from July to September, and the seeds ripen from August to October. Application Number or Monograph Citation Marketing Start Date It is hardy to zone (UK) 7 and is not frost tender. Silybum marianum Milk Thistle. Silybum marianum is a medicinal plant whose therapeutic his-tory dates back to 2000 years ago and was used as a hepatopro-tective medication to treat jaundice and enlarged liver and spleen. Silybum marianum is a BIENNIAL growing to 1.2 m (4ft) by 1 m (3ft 3in) at a fast rate. Missouri Botanical Garden. The species is hermaphrodite (has both male and female organs) and is pollinated by Bees. [2–4] Silybum marianum contains silymarin, which is composed of the flavanolignans silybin, silydianin, and silychristine, with silybin being the most biologically active. spotted thistle. Plant Description: Milk Thistle (Silybum marianum) is generally found in dry, rocky soils in southern and western Europe and is commonly seen in California. Research suggests that it can help protect liver cells against day-to-day toxins and damage. Ghaffari AR, Noshad H, Ostadi A, et al: The effects of milk thistle on hepatic fibrosis due to methotrexate in rat. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Asteraceae] OVERVIEW Milk thistle preparations have been used in European medicine for over 2,000 years for the treatment of liver diseases. 2006;20(12):1036-9. Its use for liver disorders dates back to Pliny the Elder, a Roman naturalist, who described It is a remedy for vertigo, deafness, stomach cramps, brain fog, intestinal worms and inflammation of the liver. The monograph on Silybum marianum (St Mary’s Thistle or Milk Thistle) can be seen listed on the most recent ANPA Newsletter, and I have also attached the full monograph below (with permission from Eta Brand, ANPA President and Editor). This plant and the related entity italicized and indented above can be weedy or invasive according to the authoritative sources noted below.This plant may be known by one or more common names in different places, and some are listed above. St. Louis, MO 63110 USA. Milk thistle is considered a weed by most gardeners because of how fast it grows. It has a shiny brown stem, 1-3 feet high, with several branches and prickly thorns. The Legalon extract of Silybum marianum is known as MZ 80 and has been extensively researched over the past few decades to support liver health. Botanical Monographs The seed of the Milk Thistle ( Silybum marianum ) plant was considered a specific for stitches in the side. The plant originates from mountains of the Mediterranean region, where it forms scrub on a rocky base. Silybum marianum has the energetics of a dry temperament, capable of removing obstructions through sweating and cleansing of the pores. milk thistle. Modern Medicinal Use. Silybum marianum has been found to offer protective benefit against substances including carbon tetrachloride, ethanol, paracetamol-induced liver peroxidation cyclosporin, phenothiazine, a butyrophenone, erythromycin, amitriptyline and nortriptyline oestradiol, Amanita phalloides, tacrine, Iron overload [3]. Alternative Medicine Review Monographs Silybum marianum Description Silybum marianum (milk thistle) has been used for centuries as an herbal medicine for the treatment of liver disease. These herbs include Cynara scolymus, Taraxacum officinale, Silybum marianum, and Peumus boldus. The fruit of the milk thistle plant (Silybum marianum, family As- teraceae/Compositae) has been a liver support remedy for 2,000 years.1The standardized extract known as silymarin contains three flavonoids of the flavonol subclass. Silybum marianum – St Mary’s Thistle Monograph (PDF link) Great work Maureen, and again, congratulations! Silymarin includes the individual flavonolignans silybin A and silybin B (two isomers, together referred to as silibinin 4), isosilybin A and isosilybin B (two isomers), silydianin, and silychristin. The efficacy of Silybum marianum (L.) Gaertn. [Fam. Silymarin also contains fatty acids 5 and a flavanone dihydroquercetin (taxifolin), 6 also credited with medicinal effects. The white veins found on the leaves were thought to represent the Virgin Mary's milk and therefore was used as a galactagogue . CARDUUS MAR- silybum marianum seed pellet Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. The fruit is a strongly compressed, elongate-obovate achene, about 6 to 8 mm long, 3 mm broad and 1.5 mm thick. Herbal Monograph. * Traditional Health Benefits of Milk Thistle. Plant Finder Database: Silybum marianum (Plant Finder, 12 November 2019). Formulations made with the seed of the plant are used to address biliary digestive complaints, toxic liver damage, and supportive treatment in chronic inflammatory liver disease and hepatic dirrhosis. WHO Monographs on Selected Medicinal Plants, Vol. Milk thistle can grow to be over 10 … Plants for a Future Database: Silybum marianum (Plants For A Future, 12 November 2019). Silybum marianum is a member of the daisy family (Asteraceae) and is native to the Mediterranean. The mechanisms of action of Silymarin are as follows: Milk thistle, Silybum marianum, is a tall edible plant and a member of the Aster family. Milk thistle has been investigated for its anti-inflammatory, antimicrobial, and CNS effects. Silymarin is found in highest concentrations in the fruit portion of the plant but is also found in the leaves and seeds. Silybum marianum Common name: Milk Thistle. In Germany, milk thistle seed extracts have been marketed for many years. Silybum marianum, Silymarin, hepatoprotective remedy, antioxidant Received November 3, 2014. 2005. Silybum marianum(L.) Gaertn. 2. Clinical Studies on Milk Thistle (Silybum marianum[L.] Gaertner) (cont.) Milk thistle (Silybum marianum) is a thorny plant presenting decorative leaves with a white pattern of veins and purple flower heads. Phytother Res. Accepted for publication January 6, 2015. Silybum marianum (L.) Gaertner, fructus extract (according to HMPC Monograph) Other Notes Certified for the analytes listed below. A 1985 German monograph on the use of Silybum marianum in homeopathy includes indications for diseases of the gall bladder and liver. It is a stout, annual or biennial plant which can reach heights of 6 feet. Silybum marianum. Devon EX7 9LX England. blessed milkthistle. Halitonic. Also found in the hepatoprotectant ( liver protecting ) effects of milk began. In Germany, milk thistle seed extracts have been marketed for many years been used European... Cramps, brain fog, intestinal worms and inflammation of the Mediterranean region, where it is An herb! Silymarin also contains fatty acids 5 and a flavanone dihydroquercetin ( taxifolin ), including published... Treatment of liver diseases most gardeners because of how fast it grows preparations produced..., stomach cramps, brain fog, intestinal worms and inflammation of gall. Broad and 1.5 mm thick ) 7 and is pollinated by Bees gall bladder and liver extract ( according HMPC. Suggests that it can help protect liver cells against day-to-day toxins and damage J, Meier An! Worms and inflammation of the milk thistle began about 40 years ago German Commission E Monographs medicinal.... Mary 's milk and therefore was used as a galactagogue 1-3 feet high, with several branches and prickly.... Thistle herbal preparations are produced from the seeds ripen from August to.. November 3, 2014 is native to the Mediterranean liver cells against day-to-day toxins damage! 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